Thursday, July 16, 2015
Grand Hall and Gallery, Ground Floor & 1st Floor (Maritim Hotel)
Ahmet Korkmaz
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Gulhane Military Medical Academy, Ankara, Turkey
Gul Betul Guven, Medical Student
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Gulhane Military School of Medicine, Ankara, Turkey
Ozlem Topcu, Medical Student
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Gulhane Military School of Medicine, Ankara, Turkey
Betul Hacer Demirhan, Medical Student
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Gulhane Military School of Medicine, Ankara, Turkey
Sureyya Akyildirim, Medical Student
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Gulhane Military School of Medicine, Ankara, Turkey
Yahya Cor, Medical Student
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Gulhane Military School of Medicine, Ankara, Turkey
Asel Ozturk, Medical Student
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Gulhane Military School of Medicine, Ankara, Turkey
Yalcin Gunes, Medical Student
,
Gulhane Military School of Medicine, Ankara, Turkey
Vildan Tuncbilek, Medical Student
,
Gulhane Military School of Medicine, Ankara, Turkey
Additional usage of the fructose by processed-food manufacturers is one of the big risks in terms of metabolic diseases. This situation is a serious public health problem particularly in developed countries. Besides effects on carbohydrate metabolism, fructose has been shown to affect immune system. In this study we aimed to investigate effects of fructose on gut microbiota and mucosal immunity of rats.
18 sprague-dawley rats were included. Each 6 rats were given 15% fructose and 15% glucose, respectively (by drinking water) for 6 weeks. 6 rats were included to control group. Blood sugar levels and body weights were measured every week during study. After sacrification, interleukins in intestinal tissues, biochemical tests from blood, nitrite and nitrate in urine, pathological morphology of intestines and gut microbiota were examined.
No significant difference was observed between groups in terms of weight and bacteria ratio. Fasting blood glucose, 2 Hour OGTT, T3 and T4 levels was found to be significant in glucose and fructose groups according to sham (p<0,05). Testosterone and IL-1β levels of caecum were significant in glucose group (p<0,05). IL-1β levels were higher in fructose group but not statistically significant.
Our results indicate that inflammation exists in colon and deterioration of microbiota begins. Further and long durational studies are urgently needed.
