London United Kingdom
Biographical Sketch: Tom MacDonald received a PhD in immunology from Glasgow in 1976 and then did a post-doc at the Trudeau Institute in upstate New York. In 1978 he was appointed as an assistant professor at Jefferson Medical College in Philadelphia and received tenure and promotion to Associate Professor in 1983. In 1984 he left Philadelphia and worked at Merck and Co for a year, before returning to Bart's Medical College in 1985. In 1986 he was appointed a Wellcome Trust Senior Lecturer at Bart's (till 1994), was promoted to reader in 1989, and given a personal chair at the University of London in 1991. In 2000 he moved to Southampton medical school to head up the Division of Infection, Inflammation and Repair and then in 2005 he returned to Barts and the London, as Professor of Immunology and Dean for Research. He has over 400 publications, mostly on how inappropriate immune reactions cause disease in the human gut. His H-factor is 81 with almost 23,000 citations. He was awarded FRCPath in 1995 and FMedSci in 2002 and elected a fellow of the Academy of Medical Sciences in 2002. He was a former associate editor of Gut and Gastroenterology and currently is an associate editor of Mucosal Immunology and the IBD journal.
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Papers:
Diseases at the Intestinal Surface
F.13
Identification of potential therapeutic macrophage-related targets for inflammatory bowel disease (IBD)
OR.52
Restoration of Suppressive Activity of Regulatory T-Cells from Crohn's Disease Patients Following Ex Vivo Expansion with Rapamycin. One Step Closer to Novel Cell Based Therapy?
OR.67
H3K27me3 Contributes to the Establishment of Anergic Phenotype of Intestinal Macrophages
T.67
Constitutive Type 1 Interferon Selectively Promotes STAT1-associated IL-10 Production by Human Intestinal T Cells in Health, but not IBD
T.83
Effects of narrow spectrum vs selective kinase inhibitors on the intestinal pro-inflammatory immune response in IBD
W.5
Lack of Thymic Stromal Lymphopoietin (TSLP) Down-Regulation of Mucosal Pro-Inflammatory Cytokines in Refractory Coeliac Disease (CD)
W.29
The Role of AIP (aryl hydrocarbon receptor (AhR) interacting protein) in the Human T cell Response