William Agace, PhD

Lund University - Department of Experimental Medical Science - Immunology Section
Lund Sweden
Biographical Sketch:
William Agace received a B.Sc. (Hons) in 1989 from Bristol University, UK, and a Ph.D. in Mucosal Immunology from Lund University, Sweden in 1996. Following a postdoctoral period in the Department of Rheumatology, Immunology and Allergy, at the Brigham and Women's Hospital, MA (1996-1999), he joined the Immunology Section at Lund University, Sweden, where he served as Section Head from 2005-2014. He currently is affiliated with Lund University, Sweden and the Danish Technical University, Copenhagen. His research activities focus on immune regulation in the gastrointestinal tract with specific interests in mucosal dendritic and stromal cell subsets and mucosal T cell activation, differentiation and homing. His research has resulted in several Nordic awards including the Anders Jahre Young Researcher Award in Biomedicine from the University of Oslo and the Göran Gustafsson Prize in Medicine from the Swedish Royal Academy of Sciences.
Papers:
Specialized Functions of Dedritic Cell Subsets in Intestinal Immune Homeostasis
OR.3 Lymph Borne CD8α+ DCs Are Uniquely Able to Cross-Prime CD8+ T Cells with Intestinal Epithelial Cell-Derived Antigen
OR.44 Retinoic Acid Signalling Is Required for the Efficient Differentiation of CD4+ T Cells into Pathogenic Effector Cells during the Development of Intestinal Inflammation
OR.84 IRF8-Dependent DCs Play a Key Role in the Regulation of CD8 T Cell Responses to Epithelial-derived Antigen in the Steady State but not in Inflammation
T.15 CCR9 Is Not Required for the Homing of Pro-inflammatory Effector T cells, but Is Crucial for Recruitment and Expansion of FoxP3+ CD8+ Tregs in the Small Intestine
T.76 Involvement of IRF4 dependent dendritic cells in T cell dependent colitis
W.19 IRF8-dependent migratory CD103+CD11b- dendritic cells are required for intestinal intraepithelial lymphocyte homeostasis